InterVenn Investigator Initiated Research Program in Glycoproteomics


Glycoproteomic Analysis by LC-MS and AI/ML

Venn Vista is the first commercially available panel capable of assessing blood (serum or plasma) protein glycosylation in a site-specific manner, across more than 500 peptides and glycopeptides.

InterVenn’s AI-enabled mass spectrometry glycoproteomics platform enables researchers at academic centers and biopharmaceutical companies to assess post-translational modifications at an unprecedented scale and speed. This technology empowers them to study biology and enhance drug development efforts using an -omic dimension that more closely recapitulates the disease phenotype.

  • Quantification of more than 500 glycoproteoforms in a single measurement. Protein list available upon request
  • Dynamic range: 4 orders of magnitude
  • High throughput analysis, suitable for large cohort studies
  • Sample requirement: 10 microliters of serum/plasma

Site-specific measurement of protein glycoforms provides unique insight into protein functionality that traditional immunoassays or aptamer-based approaches cannot.

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Peak Integration Platform (Open Access Software)

OpenPIP is InterVenn’s open access online portal providing state-of-the-art neural networks for mass spectrometry peak integration. Our algorithm demonstrates outstanding performances on unseen test samples, reaching near-perfect agreement (Pearson’s r 0.997) with human annotated ground truth.

OpenPIP is a straightforward alternative that overcomes the steep learning curve typical of most mass spec software offerings.

  • Reliable targeted quantification for both high and low-abundance analytes (small molecules, proteins, lipids, metabolites, etc.)
  • Ultra-fast (100 peaks/second), one-click analysis
  • Intuitive interface
  • Compatible with open formats and proprietary files
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