Glycans (carbohydrates) are one of four major classes of biomacromolecules present in all lifeforms. Driven by complex biosynthetic pathways involving genetic and environmental factors, glycans are adaptive to environmental changes. Contrary to other post-translational modifications that typically act as on/off switches, glycosylation dynamically affects protein structure and function.
Aberrant glycosylation of proteins has been implicated in key steps of disease biology, including the hallmarks of cancer as well as inflammation cascades associated with autoimmunity and aging.
Historically, glycoproteins have been analytically and computationally challenging to study at scale. Unlike DNA, RNA, and proteins, glycans are structurally complex and their synthesis is not template-based. Intervenn has built a platform that overcomes these challenges.
Watch InterVenn Co-Founder, Carolyn Bertozzi, elegantly talk about "Glycans" and their implications on holistic disease understanding.
Read A Detailed and Comparative Description on Glycoproteomics